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The
social problem
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Women's bleeding
represents a major public health problem. Current research
supports the hypothesis that a significant number of cases
of unexplained menorrhagia may be due to an underlying bleeding
disorder, the most common of which is von Willebrand disease
(VWD).
Unnecessary surgical interventions can thus be avoided with
appropriate diagnosis, and bleeding can be controlled with
medications.
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It
is thus necessary to improve: |
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Diagnosis of affected women with high risk of gynaecological
bleeding
Treatment and prophylaxis of symptoms |
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Causes
of a difficult diagnosis |
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Women's perceptions of the magnitude of their menstrual
flow often are not reliable. In particular, women with a
bleeding disorder may underestimate their losses and consider
their symptoms "normal", so that they come to
attention only after serious bleeding events
Physicians
may not suspect the diagnosis. (obstetricians and gynaecologists
may not be aware of the role that haemostasis plays in reproductive
tract bleeding and haematologist may not be appreciate the
nature or range of conditions that that can place their
patients at risk)
- Lack of availability of accurate laboratory diagnostic
tests |
Differential diagnosis of an underling
bleeding disorders in women with menorrhagia [56] |
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Gynaecological
assessment |
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Gynaecological causes
of abnormal vaginal bleeding (e.g., endometrial polyps,
submucosal fibroids, cervicitis, cervical and vaginal lesions,
etc.) should be excluded. A complete personal and family
history as well as a physical examination including a careful
pelvic/vaginal examination should be done.
An in-depth coagulation investigation should be considered
for the patient with menorrhagia in whom gynaecologic causes
have been ruled out. However, a high index of suspicion
for a possible bleeding abnormality needs to be maintained
in all patients with excessive bleeding, as the prevalence
of uterine abnormalities in patients with bleeding disorders
in whom the gynaecologic abnormality is "unmasked"
by the bleeding disorder, is uncertain. Thus, a coagulation
screen may be appropriate as part of the initial assessment,
even in the absence of a pelvic examination. |
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Medical
assessment |
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Initial testing should
include: |
platelet count
haemoglobin
/ haematocrit
ferritin
prothrombin time (PT)
activated partial thromboplastin time (APTT)
thyroid and hepatic screens
a serum prolactin |
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Further
investigations |
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A more in-depth investigation
should be considered in the following clinical situations:
the menorrhagia is present since menarche
there is evidence of anaemia or iron deficiency
there is a personal or family history of bleeding after
haemostatic challenge (dental extraction, surgery, or parturition)
or a family history of menorrhagia,
there is no local cause for menorrhagia
the first screening tests present abnormalities (such as
prolonged PT and/or PTT,
.) |
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This investigation
may include: |
bleeding time or closure time
PFA-100
blood group
von Willebrand studies (factor VIII, VWF antigen, and VWF
functional assay)
if PT, APTT or TT are prolonged: mixing tests (50:50 normal
plasma/patient's plasma)
single coagulation factor assays to test both activity and
antigen levels
These tests can be ordered by the gynaecologist
or the family physician or, alternatively, the woman may
be referred directly to the haematologist. However, interpretation
of abnormal or borderline results usually requires referral
to a haematologist (or an internal medicine) consultant.
As levels of VWF and factor VIII are affected by a number
of factors and, therefore, may fluctuate, it may be necessary
to test on more than 1 occasion if there is a positive
history but normal VWF levels on initial testing.
If there is a positive history in the absence of VWD,
further investigation may be indicated for other factor
deficiencies, platelet dysfunction, and other rare disorders
(such as a2-antiplasmin or factor XIII deficiency) that
are not evaluable by screening tests. It is important
to have a precise haematological diagnosis because the
diagnosis may affect such clinical situations as the treatment
of both gynaecologic and non-gynaecologic bleeding, the
optimal drugs/therapeutic modalities recommended for the
management of severe bleeding, guidelines for patient
preparation for surgery including preoperative and post-operative
management, and information for family counselling.
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Multidisciplinary
clinics |
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The ideal management
of women with inherited coagulation defects who suffer from
menorrhagia is through multidisciplinary clinics. However,
at the present time, very few of those clinics exist and
they are all located in tertiary care centres. These clinics
include a nurse, a clinical haematologist and a gynaecologist
who meet with the patient and liaise with the family physician.
The ideal multidisciplinary team would have an even broader
representation of expertise, and would include a laboratory
haematologist, an obstetrician-gynaecologist, an anaesthesiologist,
a family physician, a social worker, a pharmacist, a laboratory
technician, and a secretary. |
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Recommendations
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Inherited bleeding disorders should be considered in the
differential diagnosis of all patients presenting with menorrhagia.
The graphical scoring system presented is a validated tool
which offers a simple yet practical method that can be used
by patients to quantify their blood loss
Because underlying bleeding disorders are frequent in women
with menorrhagia, physicians should consider performing
a haemoglobin/haematocrit, platelet count, ferritin, PT
(INR), and APTT in women with menorrhagia. In women who
have a personal history of other bleeding or a family history
of bleeding, further investigation should be considered,
including a VWD workup (factor VIII, VWF antigen, and VWF
functional assay).
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